A lone space mercenary hunts for a bioweapon on a planet of horrors.
Samus, the protagonist of Metroid and Super Metroid, is alone. In later games, she will have sidekick computers and hunky rivals and ranting enemies, and she will comment to the player as she moves through the game, but in Super Metroid she speaks to the player only at the beginning and at the end. She is for the most part faceless and silent.
The pace of Super Metroid is for the most part a slow working through, punctuated and bookended by boss fights and disasters. The long stretches of quiet exploration are full of lonely wonders.
The musician Luminist has re-arranged the soundtracks to Metroid and Super Metroid in analog synthesizer. It is sometimes frightening, sometimes scary, always lonely.